It might work if the mouse supports it (hard to tell). If you have the adapter handy then try it, but generally you should be able to find a serial mouse off ebay or similar for a cheap price.
You'll often find MOUSE.COM on machines of that era, but almost any mouse driver will work with a simple two button MS compatible mouse on a serial port.
Being ISA, you can add a sound card quite easily too, so they aren't bad little DOS gamer machines.
Edit: just noticed it has Windows 3.1 you don't need MOUSE.COM for Windows, it'll have it's own mouse driver. You'll need the driver for DOS stuff. I always found this model a little slow in 3.1 so I took it off mine to free up disk space, they absolutely fly in MS DOS.