Unix is an operating system, the AS/400 is a computer system identified more so by it's operating system (which is almost, but not quite, completely unlike Unix).
Could a Unix have run on AS/400 hardware? I can't say. Unlikely. IBM didn't make "generic hardware", they made systems. There may well have been some commonality between the hardware in their AS/400 systems and their other Unix based systems. But any chance of loading one OS on another machine, I think, is quite unlikely.
To be clear, the hardware is not what makes the AS/400 stand out. It's the operating environment. With Unix boxes, since the Unix was, mostly, "generic", folks would buy hardware that happened to run Unix to solve their problems. The hardware that ran Unix was from a vast array of manufacturers and capability. From lowly white box PCs to huge cabinets gorged with multi processors and disk arrays.
The AS/400 was a line of computer systems running OS/400. Today it's the iSeries. The OS/400 is spectacularly unlike Unix, and it's OS/400 that makes the machines stand out.